Global gRNA Market Size Likely to Surpass at a CAGR of 19% By 2034

Market Size and Growth

As per the gRNA Market size analysis conducted by the CMI earch Team, the global gRNA market is expected to record a CAGR of 19% from 2025 to 2034. In 2025, the market size is projected to reach a valuation of USD 616 Million. By 2034, the valuation is anticipated to reach USD 2950 Million.

Overview

According to industry experts at CMI, In the CRISPR-Cas9 genome editing system, guide RNA (gRNA) is a brief portion of synthetic RNA that directs the Cas9 nuclease where to go on the DNA so that it may make exact alterations. This RNA molecule makes sure that the Cas9 protein can detect and connect to the target gene exactly. This lets it make changes like adding or deleting genes. For molecular biology research, gRNA is needed to find out more about how genes work and to produce genetic drugs. gRNA comprises two primary parts: a scaffold sequence that binds to the Cas9 protein and a sequence that is opposite to the target DNA that informs Cas9 where to cut. The market growth is influenced by several variables including growing cancer research, increasing prevalence of infectious disease and cancer, technological innovation in the area, growing R&D expenditure by the government across the globe and many others. However, the regulatory ambiguity and ethical concerns hamper the sector’s growth.

Key Trends & Drivers

• Growing partnership among the key market players: The rising partnership among the key market players is expected to offer a potential opportunity for the gRNA industry expansion. For instance, in March 2025, Integrated DNA Technologies (IDT), a global leader in genomics solutions, and Elegen, a leader in next-generation DNA manufacturing, are working together to give IDT clients early access to Elegen’s ENFINIA™ Plasmid DNA, a long and complex clonal gene synthesis service. This partnership will give IDT early access customers a cheap way to get NGS-verified 5 kb to 15 kb clonal genes supplied from Elegen’s U.S. facilities. The partnership expands IDT’s offerings in the sector. This includes genes and gene fragments like Rapid Genes, several vectors and plate formats for high-throughput workflows, and tailored solution support from a team of scientists and synthetic biology experts.
• Growing use of agricultural biotechnology: The gRNA market is expanding in agricultural biotechnology, which is a major and rising market segment since more people are adopting gene editing technologies to make crops better and make sure there is enough food. gRNA uses CRISPR technology to target and alter genes with great accuracy. This results in greater crop yields and pest and disease resistance. For example, scientists at UC Berkeley used CRISPR to make a type of rice that is immune to bacterial blight. This shows that gRNA may be used to battle illnesses that affect crops and are vital for making sure there is enough food even when the weather is bad. Syngenta’s work on CRISPR-edited crops that can survive droughts is also in high demand and has financial potential.

Report Scope

SWOT Analysis

• Strengths: The market is in high demand since it may be used for many things, such as genome engineering, functional genomics, disease modeling, epigenetics, customized medicine, and agricultural biotechnology.

• Weakness: Making GMP-grade gRNA with high quality and purity standards is expensive, which makes it hard for smaller labs or businesses that are growing to get.

• Opportunities: The Asia-Pacific and Latin America regions have more potential because of more biotech infrastructure, government funding, and new partnerships.

• Threats: The growing number of producers and alternatives in the gene editing toolkit could lead to lower prices and tighter margins.

List of the prominent players in the gRNA Market:

• Thermo Fisher Scientific Inc.
• Agilent Technologies Inc.
• System Biosciences LLC.
• Jena Bioscience GmbH
• Merck KGaA
• GENEWIZ (Azenta Life Sciences)
• Takara Bio Inc.
• Synbio Technologies
• Horizon Discovery Ltd.
• Synthego
• GenScript
• Integrated DNA Technologies Inc.
• Oligo Factory
• Creative Biolabs
• GreenLight Biosciences Inc.
• Others

The gRNA Market is segmented as follows:

By Product Type

• Synthetic gRNA
• In-vitro Transcribed (IVT) gRNA
• Plasmid-Encoded gRNA Constructs
• RNP Complexes (gRNA + Cas)
• Multiplex gRNA Libraries

By Application

• Genome Editing
• Functional Genomics Screens
• Diagnostics
• Cell & Gene Therapy
• Agricultural Biotechnology

By End User

• Academic & Research Institutes
• Biotechnology & Pharmaceutical Companies
• Contract Research Organizations (CROs)
• Hospitals & Diagnostic Laboratories
• Agro-industrial Firms

Regional Coverage:

North America

• U.S.
• Canada
• Mexico
• Rest of North America

Europe

• Germany
• France
• U.K.
• Russia
• Italy
• Spain
• Netherlands
• Rest of Europe

Asia Pacific

• China
• Japan
• India
• New Zealand
• Australia
• South Korea
• Taiwan
• Rest of Asia Pacific

The Middle East & Africa

• Saudi Arabia
• UAE
• Egypt
• Kuwait
• South Africa
• Rest of the Middle East & Africa

Latin America

• Brazil
• Argentina
• Rest of Latin America